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Moderate alcohol drinking in pregnancy increases risk for children's persistent conduct problems: causal effects in a Mendelian randomisation study.
- Source :
- Journal of Child Psychology; May2016, Vol. 57 Issue 5, p575-584, 10p, 2 Diagrams, 3 Charts
- Publication Year :
- 2016
-
Abstract
- Background Heavy alcohol use during pregnancy can cause considerable developmental problems for children, but effects of light-moderate drinking are uncertain. This study examined possible effects of moderate drinking in pregnancy on children's conduct problems using a Mendelian randomisation design to improve causal inference. Methods A prospective cohort study ( ALSPAC) followed children from their mother's pregnancy to age 13 years. Analyses were based on 3,544 children whose mothers self-reported either not drinking alcohol during pregnancy or drinking up to six units per week without binge drinking. Children's conduct problem trajectories were classified as low risk, childhood-limited, adolescence-onset or early-onset-persistent, using six repeated measures of the Strengths and Difficulties Questionnaire between ages 4-13 years. Variants of alcohol-metabolising genes in children were used to create an instrumental variable for Mendelian randomisation analysis. Results Children's genotype scores were associated with early-onset-persistent conduct problems ( OR = 1.29, 95% CI = 1.04-1.60, p = .020) if mothers drank moderately in pregnancy, but not if mothers abstained from drinking ( OR = 0.94, CI = 0.72-1.25, p = .688). Children's genotype scores did not predict childhood-limited or adolescence-onset conduct problems. Conclusions This quasi-experimental study suggests that moderate alcohol drinking in pregnancy contributes to increased risk for children's early-onset-persistent conduct problems, but not childhood-limited or adolescence-onset conduct problems. [ABSTRACT FROM AUTHOR]
- Subjects :
- BEHAVIOR disorders in children
ATTRIBUTION (Social psychology)
CHI-squared test
CHILD behavior
CONFIDENCE intervals
ALCOHOL drinking
GENETIC polymorphisms
LONGITUDINAL method
RESEARCH methodology
PROBABILITY theory
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
T-test (Statistics)
RANDOMIZED controlled trials
REPEATED measures design
DESCRIPTIVE statistics
ODDS ratio
GENOTYPES
PREGNANCY
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00219630
- Volume :
- 57
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Child Psychology
- Publication Type :
- Academic Journal
- Accession number :
- 114602949
- Full Text :
- https://doi.org/10.1111/jcpp.12486