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n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial.
- Source :
- Journal of Human Nutrition & Dietetics; Jun2016, Vol. 29 Issue 3, p345-353, 9p, 1 Diagram, 3 Charts
- Publication Year :
- 2016
-
Abstract
- Background Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus ( HCV) infected patients. n-3 polyunsaturated fatty acid ( PUFA) supplementation may reduce insulin resistance. The present study aimed to evaluate the effect of n-3 PUFA supplementation on insulin resistance in these patients. Methods In a randomised, double-blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance ( HOMA- IR ≥2.5)] were randomly divided into two groups: n-3 PUFA ( n = 25/6000 mg day<superscript>−1</superscript> of fish oil) or control ( n = 27/6000 mg day<superscript>−1</superscript> of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann-Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P < 0.05 (two-tailed) was considered statistically significant. Results Comparisons between groups showed that n-3 PUFA supplementation was more effective than the control for reducing HOMA- IR ( P = 0.015) and serum insulin ( P = 0.016). The n-3 PUFA group not only showed a significant reduction in HOMA- IR 3.8 (3.2-5.0) versus 2.4 (1.8-3.3) ( P = 0.002); serum insulin 17.1 (13.8-20.6) μ IU mL<superscript>−1</superscript> versus 10.9 (8.6-14.6) μ IU mL<superscript>−1</superscript> ( P = 0.001); and glycated haemoglobin 5.4% (5.0-5.7%) versus 5.1% (4.8-5.6%) ( P = 0.011), but also presented an increase in interleukin-1 97.5 (0.0-199.8) pg mL<superscript>−1</superscript> versus 192.4 (102.2-266.8) pg mL<superscript>−1</superscript> ( P = 0.003) and tumour necrosis factor 121.2 (0.0-171.3) pg mL<superscript>−1</superscript> versus 185.7 (98.0-246.9) pg mL<superscript>−1</superscript> ( P = 0.003). Conclusions n-3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- CONFIDENCE intervals
CYTOKINES
DIETARY supplements
FISH oils
GLYCOSYLATED hemoglobin
INSULIN
INSULIN resistance
INTERLEUKINS
LONGITUDINAL method
NUTRITION counseling
OMEGA-3 fatty acids
PROBABILITY theory
RESEARCH funding
STATISTICAL sampling
SOY oil
STATISTICAL hypothesis testing
STATISTICS
T-test (Statistics)
TUMOR necrosis factors
STATISTICAL power analysis
DATA analysis
STATISTICAL significance
RANDOMIZED controlled trials
PRE-tests & post-tests
BLIND experiment
DATA analysis software
DESCRIPTIVE statistics
CHRONIC hepatitis C
MANN Whitney U Test
GENOTYPES
GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 09523871
- Volume :
- 29
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Human Nutrition & Dietetics
- Publication Type :
- Academic Journal
- Accession number :
- 114438135
- Full Text :
- https://doi.org/10.1111/jhn.12327