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n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial.

Authors :
Freire, T. O.
Boulhosa, R. S. S. B.
Oliveira, L. P. M.
Jesus, R. P.
Cavalcante, L. N.
Lemaire, D. C.
Toralles, M. B. P.
Lyra, L. G. C.
Lyra, A. C.
Source :
Journal of Human Nutrition & Dietetics; Jun2016, Vol. 29 Issue 3, p345-353, 9p, 1 Diagram, 3 Charts
Publication Year :
2016

Abstract

Background Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus ( HCV) infected patients. n-3 polyunsaturated fatty acid ( PUFA) supplementation may reduce insulin resistance. The present study aimed to evaluate the effect of n-3 PUFA supplementation on insulin resistance in these patients. Methods In a randomised, double-blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance ( HOMA- IR ≥2.5)] were randomly divided into two groups: n-3 PUFA ( n = 25/6000 mg day<superscript>−1</superscript> of fish oil) or control ( n = 27/6000 mg day<superscript>−1</superscript> of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann-Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P < 0.05 (two-tailed) was considered statistically significant. Results Comparisons between groups showed that n-3 PUFA supplementation was more effective than the control for reducing HOMA- IR ( P = 0.015) and serum insulin ( P = 0.016). The n-3 PUFA group not only showed a significant reduction in HOMA- IR 3.8 (3.2-5.0) versus 2.4 (1.8-3.3) ( P = 0.002); serum insulin 17.1 (13.8-20.6) μ IU mL<superscript>−1</superscript> versus 10.9 (8.6-14.6) μ IU mL<superscript>−1</superscript> ( P = 0.001); and glycated haemoglobin 5.4% (5.0-5.7%) versus 5.1% (4.8-5.6%) ( P = 0.011), but also presented an increase in interleukin-1 97.5 (0.0-199.8) pg mL<superscript>−1</superscript> versus 192.4 (102.2-266.8) pg mL<superscript>−1</superscript> ( P = 0.003) and tumour necrosis factor 121.2 (0.0-171.3) pg mL<superscript>−1</superscript> versus 185.7 (98.0-246.9) pg mL<superscript>−1</superscript> ( P = 0.003). Conclusions n-3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09523871
Volume :
29
Issue :
3
Database :
Complementary Index
Journal :
Journal of Human Nutrition & Dietetics
Publication Type :
Academic Journal
Accession number :
114438135
Full Text :
https://doi.org/10.1111/jhn.12327