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Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes.
- Source :
- Clinical Ophthalmology; Mar2016, Vol. 10, p541-546, 6p
- Publication Year :
- 2016
-
Abstract
- Purpose: To evaluate the 5-year results obtained in clinical practice in the treatment of neovascular age-related macular degeneration (nAMD) with anti-VEGF agents. Materials and methods: We retrospectively analyzed all patients with nAMD who initiated anti-VEGF treatment before October 2009. We collected data regarding visual and anatomical outcomes. Results: A total of 278 patients met the selection criteria. The mean number of intravitreal injections was 5.7 in the first year and 3.7 in the fifth year. A positive mean visual acuity variation of +3.7 Early Treatment Diabetic Retinopathy Study letters occurred in the first year, but no significant differences relative to baseline were observed thereafter. The majority of patients (71%) maintained stable visual acuity throughout follow-up. At 5 years, mean central macular thickness remained substantially inferior to baseline (-96.6 µm), and 56% of patients maintained dry retinas. Conclusion: Anti-VEGF therapy leads to long-term visual stabilization in the great majority of patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11775467
- Volume :
- 10
- Database :
- Complementary Index
- Journal :
- Clinical Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 114259246
- Full Text :
- https://doi.org/10.2147/OPTH.S90913