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High-throughput sequencing of immune repertoires in multiple sclerosis.
- Source :
- Annals of Clinical & Translational Neurology; Apr2016, Vol. 3 Issue 4, p295-306, 12p
- Publication Year :
- 2016
-
Abstract
- T cells and B cells are crucial in the initiation and maintenance of multiple sclerosis (MS), and the activation of these cells is believed to be mediated through specific recognition of antigens by the T- and B-cell receptors. The antigen receptors are highly polymorphic due to recombination (T- and B-cell receptors) and mutation (B-cell receptors) of the encoding genes, which can therefore be used as fingerprints to track individual T- and B-cell clones. Such studies can shed light on mechanisms driving the immune responses and provide new insights into the pathogenesis. Here, we summarize studies that have explored the T- and B-cell receptor repertoires using earlier methodological approaches, and we focus on how high-throughput sequencing has provided new knowledge by surveying the immune repertoires in MS in even greater detail and with unprecedented depth. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
B cells
MULTIPLE sclerosis
ANTIGEN receptors
CELL receptors
Subjects
Details
- Language :
- English
- ISSN :
- 23289503
- Volume :
- 3
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Annals of Clinical & Translational Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 114191089
- Full Text :
- https://doi.org/10.1002/acn3.295