1,2:5,6-Di- O-Cyclohexylidene- d-Mannitol and Its Bis(Trimethylsilyl) Ether in the Dithiophosphorylation Reactions.

ABSTRACT The reaction of 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-disulfide with diketonide of d-mannitol has been found to give optically active bisaryldithiophosphonic acids transformed into the corresponding diammonium salts by the treatment of n-hexadecylamine. O, O-Bis(trimethylsilyl) ether of d-mannitol ketonide reacts with 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-disulfide to form chiral S, S-disilylbisaryldithiophosphonate. Diammonium bisaryldithiophosphonate possesses antibacterial activity against Staphylococcus aureus ATCC 6538-P. [ABSTRACT FROM AUTHOR]