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Tc-Mesalamine as potential agent for diagnosis and monitoring of ulcerative colitis: labelling, characterisation and biological evaluation.

Tc-Mesalamine as potential agent for diagnosis and monitoring of ulcerative colitis: labelling, characterisation and biological evaluation.

Authors :
El-Kawy, O.
Sanad, M.
Marzook, F.
Source :
Journal of Radioanalytical & Nuclear Chemistry; Apr2016, Vol. 308 Issue 1, p279-286, 8p, 2 Diagrams, 2 Charts, 8 Graphs
Publication Year :
2016

Abstract

Mesalamine was labelled with technetium-99m (Tc) in high radiolabelling yield (~98.4 %), in vitro stability (~4 h) and in serum persistence (~24 h). Optimum labelling conditions were investigated. The structure of the complex was confirmed using in silico analysis. Molecular docking was performed to evaluate the complex binding to its biochemical target, the PPARĪ³ receptor. Biodistribution and clearance studies were performed in normal and ulcerative colitis models in mice. The tracer's localization was highest (~65.2 %) in microbial model compared to chemical model (~42.4 %) and normal mice (~22.1 %) at 60 min post injection. All data supported the usefulness of Tc-mesalamine as a radiotracer for ulcerative colitis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02365731
Volume :
308
Issue :
1
Database :
Complementary Index
Journal :
Journal of Radioanalytical & Nuclear Chemistry
Publication Type :
Academic Journal
Accession number :
113707124
Full Text :
https://doi.org/10.1007/s10967-015-4338-4