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Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial.
- Source :
- American Journal of Clinical Nutrition; 3/1/2016, Vol. 103 Issue 3, p926-933, 8p
- Publication Year :
- 2016
-
Abstract
- Background: The utility of dairy ingredients in the supplementary foods used in the treatment of childhood moderate acute malnutrition (MAM) remains unsettled. Objective: We evaluated the effectiveness of a peanut-based ready-to-use supplementary food (RUSF) with soy protein compared with a novel RUSF containing dairy ingredients in the form of whey permeate and whey protein concentrate in the treatment of children with MAM. Design: We conducted a randomized, double-blind clinical effectiveness trial involving rural Malawian and Mozambican children 6-59 mo of age with MAM treated with either soy RUSF or a novel whey RUSF treatment of ~75 kcal ⋅ kg<superscript>-1</superscript> ⋅ d<superscript>-1</superscript> for up to 12 wk. Results: The proportion of children that recovered from MAM was significantly higher in the group that received whey RUSF (960 of 1144; 83.9%) than in the group that received soy RUSF (874 of 1086; 80.5%; P, 0.04; risk difference 3.4%, 95% CI: 0.3%, 6.6%). Children who consumed whey RUSF also demonstrated better growth markers, with a higher mean midupper arm circumference (MUAC) at the time of discharge (P < 0.009), greater MUAC gain during the course of treatment (P < 0.003), higher mean weight-for-height z score at discharge (P < 0.008), and greater weight gain (P < 0.05). No significant differences were identified in length gain or time to recovery between the 2 groups. Conclusion: This study highlights the importance of milk protein in the treatment of MAM, because the use of a novel whey RUSF resulted in higher recovery rates and improved growth than did soy RUSF, although the whey RUSF supplement provided less total protein and energy than the soy RUSF. This study was registered at clinicaltrials.gov as NCT01790048. [ABSTRACT FROM AUTHOR]
- Subjects :
- FOOD quality
MALNUTRITION treatment
ANTHROPOMETRY
ARM
BIOAVAILABILITY
CAREGIVERS
CHI-squared test
CHILD development
CHILDREN'S health
CHILD nutrition
CONFIDENCE intervals
CONVALESCENCE
DIETARY supplements
FISHER exact test
INFANTS
INFANT development
INFANT nutrition
INTERVIEWING
MILK proteins
NUTRITIONAL assessment
NUTRITIONAL requirements
PEANUTS
PROBABILITY theory
QUESTIONNAIRES
REFERENCE values
RESEARCH funding
STATISTICAL sampling
SOY proteins
STATISTICAL hypothesis testing
T-test (Statistics)
WEIGHT gain
STATISTICAL significance
RANDOMIZED controlled trials
BLIND experiment
DATA analysis software
DESCRIPTIVE statistics
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 103
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 113556018
- Full Text :
- https://doi.org/10.3945/ajcn.115.124636