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Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.

Authors :
Skurnik, David
Clermont, Olivier
Guillard, Thomas
Launay, Adrien
Danilchanka, Olga
Pons, Stéphanie
Diancourt, Laure
Lebreton, François
Kadlec, Kristina
Roux, Damien
Jiang, Deming
Dion, Sara
Aschard, Hugues
Denamur, Maurice
Cywes-Bentley, Colette
Schwarz, Stefan
Tenaillon, Olivier
Andremont, Antoine
Picard, Bertrand
Mekalanos, John
Source :
Molecular Biology & Evolution; Apr2016, Vol. 33 Issue 4, p898-914, 17p
Publication Year :
2016

Abstract

In the context of the great concern about the impact of human activities on the environment, we studied 403 commensal Escherichia coli/Escherichia clade strains isolated from several animal and human populations that have variable contacts to one another. Multilocus sequence typing (MLST) showed a decrease of diversity 1) in strains isolated from animals that had an increasing contact with humans and 2) in all strains that had increased antimicrobial resistance. A specific B1 phylogroup clonal complex (CC87, Institut Pasteur schema nomenclature) of animal origin was identified and characterized as being responsible for the increased antimicrobial resistance prevalence observed in strains from the environments with a high human-mediated antimicrobial pressure. CC87 strains have a high capacity of acquiring and disseminating resistance genes with specific metabolic and genetic determinants as demonstrated by high-throughput sequencing and phenotyping. They are good mouse gut colonizers but are not virulent. Our data confirm the predominant role of human activities in the emergence of antimicrobial resistance in the environmental bacterial strains and unveil a particular E. coli clonal complex of animal origin capable of spreading antimicrobial resistance to othermembers of microbial communities. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07374038
Volume :
33
Issue :
4
Database :
Complementary Index
Journal :
Molecular Biology & Evolution
Publication Type :
Academic Journal
Accession number :
113496557
Full Text :
https://doi.org/10.1093/molbev/msv280