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Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins.
- Source :
- Obesity (19307381); Mar2016, Vol. 24 Issue 3, p750-756, 7p
- Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>This study aimed to examine the gene-environment interaction of physical activity and body mass index (BMI) using the Chinese National Twin Registry (CNTR).<bold>Methods: </bold>A total of 19,308 same-sex adult twins from CNTR were included in the analysis. Twin zygosity was determined by self-reported questionnaire. Height and weight were measured using self-reported questionnaire. The vigorous physical activity was defined as greater or equal to five times a week of at least 30 min moderate- or high-intensity physical activity. A twin structural equation model was used to analyze the gene-environment interaction of vigorous exercise with BMI among 13,506 monozygotic twins and 5,802 dizygotic twins.<bold>Results: </bold>A structural equation model adjusting for age and sex found vigorous exercise significantly moderated the additive genetic effects (P < 0.001) and shared environmental effects (P < 0.001) on BMI. The genetic contributions to BMI were significantly lower for people who adopted a physically active lifestyle [h(2) = 40%, 95% confidence interval (CI): 35%-46%] than those who were relative sedentary (h(2) = 59%, 95% CI: 52%-66%). The observed gene-physical activity interaction was more pronounced in men than women.<bold>Conclusions: </bold>Our results suggested that adopting a physically active lifestyle may help to reduce the genetic influence on BMI among the Chinese population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19307381
- Volume :
- 24
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Obesity (19307381)
- Publication Type :
- Academic Journal
- Accession number :
- 113308941
- Full Text :
- https://doi.org/10.1002/oby.21402