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Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea.
- Source :
- Angiology; Apr2016, Vol. 67 Issue 4, p364-374, 11p
- Publication Year :
- 2016
-
Abstract
- Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) morbidity and mortality. Endocan is a surrogate endothelial dysfunction marker that may be associated with CV risk factors. In this study, we tested whether serum endocan is a biomarker for OSA. Serum endocan levels were measured at baseline in 40 patients with OSA and 40 healthy controls and after 3 months of continuous positive airway pressure (CPAP) treatment in the patients with OSA. All participants were evaluated by full polysomnography. Flow-mediated dilatation (FMD) and carotid intima media thickness (cIMT) were measured in all participants. Endocan levels were significantly higher in patients with OSA than in healthy controls. After adjusting confounders, endocan was a good predictor of OSA. Endocan levels correlated with OSA severity (measured by the apnea–hypopnea index [AHI]). After 3 months of CPAP treatment, endocan levels significantly decreased. Endocan levels were significantly and independently correlated with cIMT and FMD after multiple adjustments. The cIMT and FMD also had significant and independent correlation with AHI. Endocan might be a useful marker for the predisposition of patients with OSA to premature vascular disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARDIOVASCULAR disease related mortality
SLEEP apnea syndrome treatment
ACADEMIC medical centers
BIOMARKERS
BLOOD vessels
CARDIOVASCULAR diseases risk factors
CHI-squared test
STATISTICAL correlation
ENDOTHELIUM
LONGITUDINAL method
MULTIVARIATE analysis
PROBABILITY theory
QUESTIONNAIRES
SLEEP apnea syndromes
STATISTICS
T-test (Statistics)
LOGISTIC regression analysis
POLYSOMNOGRAPHY
DATA analysis
CONTINUOUS positive airway pressure
DATA analysis software
DESCRIPTIVE statistics
CAROTID intima-media thickness
MANN Whitney U Test
KRUSKAL-Wallis Test
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 67
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 113293103
- Full Text :
- https://doi.org/10.1177/0003319715590558