Back to Search
Start Over
Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice.
- Source :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Mar2016, Vol. 71 Issue 3, p290-299, 10p, 1 Diagram, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- In the present study, the possibility that a diabetic (DM) status might worsen age-related bone deterioration was explored in mice. Male CD-1 mice aged 2 (young control group) or 16 months, nondiabetic or made diabetic by streptozotocin injections, were used. DM induced a decrease in bone volume, trabecular number, and eroded surface, and in mineral apposition and bone formation rates, but an increased trabecular separation, in L1-L3 vertebrae of aged mice. Three-point bending and reference point indentation tests showed slight changes pointing to increased frailty and brittleness in the mouse tibia of diabetic old mice. DM was related to a decreased expression of both vascular endothelial growth factor and its receptor 2, which paralleled that of femoral vasculature, and increased expression of the pro-adipogenic gene peroxisome proliferator-activated receptor γ and adipocyte number, without affecting β-catenin pathway in old mouse bone. Concomitant DM in old mice failed to affect total glutathione levels or activity of main anti-oxidative stress enzymes, although xanthine oxidase was slightly increased, in the bone marrow, but increased the senescence marker caveolin-1 gene. In conclusion, DM worsens bone alterations of aged mice, related to decreased bone turnover and bone vasculature and increased senescence, independently of the anti-oxidative stress machinery. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIABETES
AGE factors in disease
STREPTOZOTOCIN
VASCULAR endothelial growth factor receptors
PEROXISOME proliferator-activated receptors
LABORATORY mice
DIABETES complications
OSTEOPOROSIS diagnosis
BONE remodeling
AGING
ANIMAL experimentation
BONE growth
COMPUTED tomography
LUMBAR vertebrae
MICE
OSTEOPOROSIS
BONE density
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 71
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 113124199
- Full Text :
- https://doi.org/10.1093/gerona/glv160