Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren's syndrome: a pilot study.

Aims The aims of this study were as follows: (i) To assess the prevalence of periodontitis among patients with primary Sjögren's syndrome ( pSS) and comparator groups of patients with rheumatoid arthritis ( RA) and osteoarthritis ( OA). (ii) To perform a pilot study to compare serum antibody responses to 10 oral/periodontal bacteria in these patient groups and a historical comparator group of patients with periodontitis. Materials and Methods Standard clinical periodontal assessments were performed on 39 pSS, 36 RA and 23 OA patients and 'In-house' antibody ELISAs for serum antibodies against 10 oral/periodontal bacteria were performed in these groups. Results Forty-six percent of the pSS group, 64% of the RA group and 48% of the OA group had moderate/severe periodontitis. These frequencies did not reach statistical significance between groups. Raised antibody levels to Prevotella denticola were found in the pSS, RA and periodontitis groups compared to the OA group. Significant between group differences were seen for Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Campylobacter showae. None of these differences were specifically associated with pSS. Conclusion This study showed no increase in periodontitis in pSS patients. Although the P. denticola data are of interest, identifying bacterial triggering factors for pSS will likely require alternative strategies including modern techniques such as microbiome analysis. [ABSTRACT FROM AUTHOR]