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Depression predicts persistence of paranoia in clinical high-risk patients to psychosis: results of the EPOS project.
- Source :
- Social Psychiatry & Psychiatric Epidemiology; Feb2016, Vol. 51 Issue 2, p247-257, 11p
- Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>The link between depression and paranoia has long been discussed in psychiatric literature. Because the causality of this association is difficult to study in patients with full-blown psychosis, we aimed to investigate how clinical depression relates to the presence and occurrence of paranoid symptoms in clinical high-risk (CHR) patients.<bold>Methods: </bold>In all, 245 young help-seeking CHR patients were assessed for suspiciousness and paranoid symptoms with the structured interview for prodromal syndromes at baseline, 9- and 18-month follow-up. At baseline, clinical diagnoses were assessed by the Structured Clinical Interview for DSM-IV, childhood adversities by the Trauma and Distress Scale, trait-like suspiciousness by the Schizotypal Personality Questionnaire, and anxiety and depressiveness by the Positive and Negative Syndrome Scale.<bold>Results: </bold>At baseline, 54.3% of CHR patients reported at least moderate paranoid symptoms. At 9- and 18-month follow-ups, the corresponding figures were 28.3 and 24.4%. Depressive, obsessive-compulsive and somatoform disorders, emotional and sexual abuse, and anxiety and suspiciousness associated with paranoid symptoms. In multivariate modelling, depressive and obsessive-compulsive disorders, sexual abuse, and anxiety predicted persistence of paranoid symptoms.<bold>Conclusion: </bold>Depressive disorder was one of the major clinical factors predicting persistence of paranoid symptoms in CHR patients. In addition, obsessive-compulsive disorder, childhood sexual abuse, and anxiety associated with paranoia. Effective pharmacological and psychotherapeutic treatment of these disorders and anxiety may reduce paranoid symptoms in CHR patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- MENTAL depression
PARANOIA
PSYCHOSES
SYMPTOMS
DISEASE complications
MEDICAL literature
THERAPEUTICS
COMPARATIVE studies
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
MENTAL status examination
MYERS-Briggs Type Indicator
PSYCHOLOGICAL tests
RESEARCH
RESEARCH funding
RISK assessment
EVALUATION research
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09337954
- Volume :
- 51
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Social Psychiatry & Psychiatric Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 112860656
- Full Text :
- https://doi.org/10.1007/s00127-015-1160-9