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Pediatric liver diseases: current challenges and future perspectives.

Authors :
Della Corte, Claudia
Mosca, Antonella
Vania, Andrea
Alterio, Arianna
Alisi, Anna
Nobili, Valerio
Source :
Expert Review of Gastroenterology & Hepatology; Feb2016, Vol. 10 Issue 2, p255-265, 11p
Publication Year :
2016

Abstract

Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma. The prevalence of liver diseases in children is unknown. In the USA, every year, 15,000 children are hospitalized for liver diseases, but these disorders continue to be under-recognized or diagnosed late. The main reason is due to the frequent absence of symptoms in the vast majority of liver diseases, especially in the early stages. In the last few decades several advances have been made in understanding the pathogenesis of liver diseases, permitting the discovery of new therapeutic targets to treat liver diseases, thus improving the natural history of these disorders. In this article we discuss the most recent advances in the understanding of the pathogenesis, diagnosis and treatment of the most frequent pediatric liver diseases. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
17474124
Volume :
10
Issue :
2
Database :
Complementary Index
Journal :
Expert Review of Gastroenterology & Hepatology
Publication Type :
Academic Journal
Accession number :
112684841
Full Text :
https://doi.org/10.1586/17474124.2016.1129274