In vitro pharmacological screening of three newly synthesised pyrimidine derivatives.

The antibacterial and antifungal activities of three new pyrimidine derivatives, namely, 2,6-bis(4,6-dimethylpyrimidin-2-ylthio)benzene-1,4-diol (1),3,5-bis(4,6-dimethylpyrimidin- 2-ylthio)-2-methylbenzene-1,4-diol (2) and 3,5-bis(4,6-dimethylpyrimidin-2- ylthio)-2-methoxybenzene-1,4-diol (3), synthesised by electrochemical method are presented here. The compounds were screened for their activities against Grampositive and Gram-negative bacteria, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and a pathogenic fungus Aspergillus niger. The results show that these compounds have significant activity against these bacteria and fungus. The minimum inhibitory concentration of compound 1 was determined as 62.5 µg/mL against B. subtilis, 125 µg/mL against E. coli and 250 µg/mL against S. aureus establishing its promising activities higher than susceptible ranges. [ABSTRACT FROM AUTHOR]