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Calculated Platelet Dose: Is It Useful in Clinical Practice?

Authors :
Askari, S.
Burt, M.
Weik, P.
Crosson, J.
Source :
Transfusion; Sep2001 Supplement 1, Vol. 41, p11S-11S, 1/2p, 1 Chart
Publication Year :
2001

Abstract

Background: The corrected count increment (CCI) can standardize assessment of platelet transfusions by correcting for patient's body surface area (BSA) and platelet dose (PD). By using a fixed CCI and a desired post-transfusion platelet count, CCI formula can be used to calculate PD based on patient's BSA. Our transfusion service has used the following formula since May 1990, to determine the PD for non-bleeding patients: PD = (Desired post minus pro-transfusion platelet count/mL) × (BSA in m²)/(7000/mL × 1.7), where PD is expressed in number of platelet concentrates, 7000 is the expected platelet count increment per unit transfused, and 1.7 is BSA in m² in a 70-kilogram adult. This study evaluated the clinical value of this approach. Methods: A retrospective review was performed of all 2202 platelet transfusions at our hospital between 1/1/98 and 12/31/00. In 89 cases a calculated PD was determined prior to transfusion and these were evaluated for platelet increments at 1, 1-18, or 18-24 hours post-transfusion. The transfusions that used the calculated PD were compared with those that did not. Results: 83 transfusions in 69 patients were reviewed (see table). The background clinical conditions were: miscellaneous uncomplicated cases 49%, sepsis 25%, hematological malignancy 16%, coagulopathy secondary to alcoholic hepatitis 6%, and solid tumor 4%. No difference in mean platelet count increments was noted between the two groups (p=0.46). Conclusion: While calculated platelet dose can reduce the number of donor exposures and also identify cases that need more than the conventional dose based on BSA, its overall impact on platelet transfusion response appears less significant. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00411132
Volume :
41
Database :
Complementary Index
Journal :
Transfusion
Publication Type :
Academic Journal
Accession number :
11257838