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Testing the Assessment of New Radiation Oncology Technology and Treatments framework using the evaluation of post-prostatectomy radiotherapy techniques.
- Source :
- Journal of Medical Imaging & Radiation Oncology; Feb2016, Vol. 60 Issue 1, p129-137, 9p
- Publication Year :
- 2016
-
Abstract
- <bold>Introduction: </bold>We tested the ability of the Assessment of New Radiation Oncology Technology and Treatments framework to determine the clinical efficacy and safety of intensity-modulated radiation therapy (IMRT) compared with 3-dimensional radiation therapy (3DCRT) for post-prostatectomy radiation therapy (PPRT) to support its timely health economic evaluation.<bold>Methods: </bold>Treatment plans produced using FROGG guidelines provided dosimetry parameters for both techniques at 64 Gy and 70 Gy and were also used to model early and late outcome probabilities. Clinical parameters were derived from early toxicity and quality of life patient data, systematic literature review and expert opinion. Dosimetry parameters were correlated with the measures of clinical efficacy and safety.<bold>Results: </bold>Data from two patient cohorts (29 and 27 respectively) were collected within the project timeframe, providing evidence for acute toxicity and quality of life, and dosimetric comparisons. Relative rates of tumour control probability (TCP) and normal tissue control probability (NTCP) modelling were readily derived from the planning exercise and demonstrated advantages in uncomplicated TCP for IMRT over 3DCRT, predominantly due to normal tissue sparing. The safety of IMRT delivery was demonstrated with TCP uncompromised by IMRT protocol violations, which achieved rectal sparing only by reducing minimum target dose and coverage.<bold>Conclusion: </bold>Sources of desk-top and patient-based evidence were successfully used to demonstrate potential improved clinical efficacy and safety of applying dose escalation using IMRT instead of 3DCRT in PPRT. [ABSTRACT FROM AUTHOR]
- Subjects :
- TREATMENT effectiveness
RADIOTHERAPY treatment planning
RADIATION dosimetry
PROSTATECTOMY
QUALITY of life
MEDICAL economics
PROSTATE tumors treatment
COMPARATIVE studies
RESEARCH methodology
MEDICAL cooperation
PROSTATE tumors
RADIATION doses
RADIATION injuries
RADIOTHERAPY
RESEARCH
SURVIVAL analysis (Biometry)
SURVIVAL
EVALUATION research
DISEASE incidence
ECONOMICS
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 17549477
- Volume :
- 60
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Medical Imaging & Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 112506120
- Full Text :
- https://doi.org/10.1111/1754-9485.12390