Back to Search Start Over

Biochanin A Ameliorates Arsenic-Induced Hepato- and Hematotoxicity in Rats.

Authors :
Jalaludeen, Abdulkadhar Mohamed
Woo Tae Ha
Ran Lee
Jin Hoi Kim
Jeong Tae Do
Chankyu Park
Young Tae Heo
Won Young Lee
Hyuk Song
Source :
Molecules; Jan2016, Vol. 21 Issue 1, p69, 14p
Publication Year :
2016

Abstract

Biochanin A (BCA) is a natural organic compound of the phytoestrogenic isoflavone class that has antioxidant and metal chelator properties in the presence of transition metal ions, however, its efficacy in animal models is still obscure. Therefore, the objective of this study was to investigate the protective effects of BCA against arsenic-induced hepatic injury and hematotoxicity in rats. The results suggest that arsenic intoxicated rats showed significantly higher levels of plasma hepatic markers than normal control rats. Furthermore, an increase in lipid peroxidation with depletion of reduced glutathione (GSH) and activities of superoxide dismutase (SOD) and catalase (CAT) occurred in the livers of rats exposed to arsenic. Administration of BCA (20 mg/kg⋅bw/day) and selenium (3 mg/kg⋅bw/day) resulted in a significant reversal of hepatic and oxidative stress markers in arsenic-intoxicated rats. A low dose of BCA (10 mg/kg⋅bw/day) did not show any preventive effect, while a high dose of BCA (40 mg/kg⋅bw/day) partially prevented all hepatotoxicity events. These biochemical perturbations were supported by histopathological observations of the liver. Our results suggest that administration of BCA (20 mg/kg⋅bw/day) attenuated the arsenic hepatotoxicity, a property that could contribute to the therapeutic approaches for chronic liver diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
21
Issue :
1
Database :
Complementary Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
112469601
Full Text :
https://doi.org/10.3390/molecules21010069