Back to Search Start Over

Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease.

Authors :
Zheng, Yuan
Wei, Jing
Zhou, Bu-Yu
Xu, Yi
Dong, Jian-Hua
Guan, Lu-Yuan
Ma, Ping
Yu, Peng-Bo
Wang, Jing-Jun
Source :
Infectious Diseases; Apr2016, Vol. 48 Issue 4, p262-266, 5p
Publication Year :
2016

Abstract

BackgroundChina has the highest prevalence of hemorrhagic fever with renal syndrome (HFRS) and accounts for 90% of the total cases worldwide. However, the long-term persistence of anti-hantavirus antibodies in sera of patients with HFRS and subjects vaccinated against the disease remains unclear. The aim of the present study was to investigate the prevalence of anti-hantavirus IgG antibodies in sera of patients with prior HFRS, versus subjects vaccinated against the disease and controls in Shaanxi, China.MethodsSix hundred individuals were included in this study. We quantified anti-hantavirus IgG antibodies in HFRS patients (n = 100), vaccinees (n = 200), controls from endemic regions (n = 200), and controls from non-endemic regions (n = 100) in China.ResultsThe median optical density (OD) values (range) were 0.803 (0.008–1.813), 0.075 (0.004–1.565), 0.026 (0–1.179), and 0.015 (0.009–0.118) for HFRS patients, vaccinated subjects, endemic controls, and non-endemic controls, respectively. There was a strikingly significant difference between the HFRS group and each non-HFRS group (p < 0.001). The vaccinated subjects were also significantly different from the endemic controls. The time since the acute phase was correlated with the OD values of the HFRS patients.ConclusionsOur study suggests that HFRS patients gain long-lasting protection and that vaccination may be an effective way to stimulate antibody production. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
23744235
Volume :
48
Issue :
4
Database :
Complementary Index
Journal :
Infectious Diseases
Publication Type :
Academic Journal
Accession number :
112454930
Full Text :
https://doi.org/10.3109/23744235.2015.1121289