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Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease.

Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease.

Authors :
Heebøll, Sara
Kreuzfeldt, Martin
Hamilton-Dutoit, Stephen
Kjær Poulsen, Marianne
Stødkilde-Jørgensen, Hans
Møller, Holger Jon
Jessen, Niels
Thorsen, Kasper
Kristina Hellberg, Ylva
Bønløkke Pedersen, Steen
Grønbæk, Henning
Source :
Scandinavian Journal of Gastroenterology; Apr2016, Vol. 51 Issue 4, p456-464, 9p
Publication Year :
2016

Abstract

Objective“The obesity epidemic” has led to an increase in obesity-related conditions including non-alcoholic fatty liver disease (NAFLD), for which effective treatments are in demand. The polyphenol resveratrol prevents the development of experimental NAFLD through modulation of cellular pathways involved in calorie restriction. We aimed to test the hypothesis that resveratrol alleviates NAFLD in a randomised, clinical trial.Materials and methodsA total of 28 overweight patients with transaminasemia and histological NAFLD were randomised 1:1 to placebo or resveratrol 1.5 g daily for 6 months. Twenty-six participants completed the trial and underwent repeated clinical investigation, blood work, MR spectroscopy; and 19 participants agreed to a repeat liver biopsy.ResultsResveratrol treatment was generally not superior to placebo in improving plasma markers of liver injury (primary outcome: alanine transaminase,p = 0.51). Resveratrol-treated patients showed a 3.8% decrease in liver lipid content (p = 0.03), with no difference between the two treatment arms (p = 0.38) and no improvement of histological features. Resveratrol treatment was not associated with improvements in insulin sensitivity or markers of the metabolic syndrome, except for a transient decrease in systolic BP. Microarray analysis and qRT-PCR revealed no major changes in expression profile. Also, we report a serious adverse event in a patient who developed fever and bicytopenia.ConclusionsIn this placebo-controlled, high-dose and long-term study, resveratrol treatment had no consistent therapeutic effect in alleviating clinical or histological NAFLD, though there may be a small ameliorating effect on liver function tests and liver fat accumulation. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
00365521
Volume :
51
Issue :
4
Database :
Complementary Index
Journal :
Scandinavian Journal of Gastroenterology
Publication Type :
Academic Journal
Accession number :
112357589
Full Text :
https://doi.org/10.3109/00365521.2015.1107620