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Effect of Vascular Risk Factors and Diseases on Mortality in Individuals with Dementia: A Systematic Review and Meta-Analysis.
- Source :
- Journal of the American Geriatrics Society; Jan2016, Vol. 64 Issue 1, p37-46, 10p, 3 Diagrams, 2 Charts
- Publication Year :
- 2016
-
Abstract
- Objectives To assess the effect of cardiovascular diseases and risk factors on mortality in individuals with dementia. Design Systematic review and meta-analysis. English- and Dutch-language studies in PubMed, EMBASE, and PsycINFO databases were searched in April 2014 with hand-searching of in-text citations and no publication limitations. Inclusion criteria were original studies reporting on cardiovascular risk factors or diseases and their relationship with survival in individuals with dementia. The Quality In Prognosis Studies tool was used to appraise all included articles. Setting Population-, hospital-, and nursing home-based. Participants Community-dwelling, hospitalized individuals and nursing home residents with dementia. Measurements A random-effects meta-analysis was performed to investigate the effect of several cardiovascular diseases and risk factors on overall mortality. Results Twelve studies with 235,865 participants were included. In pooled analyses, male sex (hazard ratio ( HR) = 1.67, 95% confidence interval ( CI) = 1.56-1.78), diabetes mellitus ( DM) ( HR = 1.49, 95% CI = 1.33-1.68), smoking (ever vs never) ( HR = 1.37, 95% CI = 1.17-1.61), coronary heart disease ( CHD) ( HR = 1.21, 95% CI = 1.02-1.44) and congestive heart failure ( CHF) ( HR = 1.37, 95% CI = 1.18-1.59) were associated with mortality. Stroke, high blood pressure, being overweight, and hypercholesterolemia were not statistically significantly related to mortality. Conclusion Individuals with dementia and DM, smoking, CHD, and CHF have a greater risk of death than individuals with dementia without these risk factors or diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- VASCULAR diseases
DEATH rate
DEMENTIA patients
DIABETES
MORTALITY
NURSING home patients
PEOPLE with diabetes
CARDIOVASCULAR disease related mortality
DISEASES
PATIENTS
RESEARCH
CARDIOVASCULAR diseases
CARDIOVASCULAR diseases risk factors
CONFIDENCE intervals
CORONARY disease
DEMENTIA
HEART failure
HYPERCHOLESTEREMIA
HYPERTENSION
MEDICAL information storage & retrieval systems
PSYCHOLOGY information storage & retrieval systems
MEDICAL cooperation
MEDLINE
META-analysis
MULTIVARIATE analysis
ONLINE information services
PROBABILITY theory
RESEARCH funding
SEX distribution
SMOKING
STATISTICS
STROKE
DATA mining
SYSTEMATIC reviews
DATA analysis
BODY mass index
RELATIVE medical risk
RESEARCH bias
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
EVALUATION
PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 64
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 112357004
- Full Text :
- https://doi.org/10.1111/jgs.13835