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Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese Health Study.
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry; Jan2016, Vol. 87 Issue 1, p86-92, 7p, 4 Charts
- Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Prospective studies on lipids and risk of Parkinson's disease (PD) in Asian populations are sparse. This study prospectively examined the associations between dietary cholesterol and major fatty acids, and risk of PD among the Chinese in Singapore.<bold>Methods: </bold>This study used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63 257 men and women aged 45-74 years in Singapore enrolled in 1993-1998. Dietary intakes of cholesterol and fatty acids were derived from a validated semiquantitative food frequency questionnaire and the Singapore Food Composition Table. Incident PD cases were identified either through follow-up interviews or record linkage analysis with hospital discharge and PD outpatient registries.<bold>Results: </bold>After an average of 14.6 years, 218 men and 193 women in the cohort developed PD. Dietary cholesterol was associated with statistically significantly lower risk of PD in a dose-dependent manner among men after adjustment for established risk factors for PD and intakes of major fatty acids. Compared to the lowest quartile, HR (95% CI) for the highest quartile was 0.53 (95% CI 0.33 to 0.84) (P for trend=0.006). Among women, dietary monounsaturated fatty acid was inversely associated with PD risk (P for trend=0.033). Compared to the lowest quartile, HR for the highest quartile was 0.44 (95% CI 0.22 to 0.88). There was no statistically significant association between dietary saturated, n-3 and n-6 fatty acids and PD risk.<bold>Conclusions: </bold>Higher intakes of cholesterol and monounsaturated fatty acids may reduce risk of PD in men and women, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- PARKINSON'S disease
DISEASE risk factors
HOSPITAL admission & discharge
DISEASE incidence
CHOLESTEROL in the body
DIET in disease
MONOUNSATURATED fatty acids
DIET
DOSE-effect relationship in pharmacology
FATTY acids
CHOLESTEROL content of food
FAT content of food
LONGITUDINAL method
MEDICAL record linkage
QUESTIONNAIRES
RESEARCH funding
UNSATURATED fatty acids
DISCHARGE planning
RELATIVE medical risk
FOOD diaries
Subjects
Details
- Language :
- English
- ISSN :
- 00223050
- Volume :
- 87
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 112011178
- Full Text :
- https://doi.org/10.1136/jnnp-2014-310065