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Association of onabotulinum toxin A treatment with salivary pH and dental caries of neurologically impaired children with sialorrhea.
- Source :
- International Journal of Paediatric Dentistry; Jan2016, Vol. 26 Issue 1, p45-51, 7p, 4 Charts
- Publication Year :
- 2016
-
Abstract
- Background. Sialorrhea is a common manifestation of several neurological disorders. The use of intraglandular onabotulinum toxin A (OBTXA) injection has been recognized to effectively treat sialorrhea. As OBTXA injection reduces salivary flow rate and alters salivary quality, its use may have a detrimental effect on oral health. Aim. To examine the effect of OBTXA injection on caries experience and salivary pH of neurologically impaired children with sialorrhea. Design. Twenty-five children receiving OBTXA treatment and 25 control children were enrolled in the study. Whole saliva was collected to determine salivary pH. All participants underwent an interview on their dietary habits. Dental clinical examinations were carried out to evaluate caries experience and oral hygiene level. Results. Overall, mean salivary pH value was significantly lower in the OBTXA group (6.92 ± 0.77) compared with the control group (7.36 ± 0.70). Caries activity was significantly higher in the OBTXA group (P = 0.01). The regression analyses showed a significant association between OBTXA treatment and salivary pH value (P = 0.03). Results from the logistic regression show that dental caries was significantly associated with OBTXA treatment (OR = 1.73, CI = 1.14-27.3). Conclusions. The study showed an intricate relationship between OBTXA treatment and oral findings. Hence, special dental care should be given to children receiving OBTXA treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEALTH
THERAPEUTICS
DENTAL caries risk factors
SALIVA
BOTULINUM toxin
CHILDREN'S health
CONFIDENCE intervals
STATISTICAL correlation
DROOLING
INJECTIONS
ORAL hygiene
NEUROLOGICAL disorders
QUESTIONNAIRES
STATISTICS
T-test (Statistics)
TOXINS
LOGISTIC regression analysis
DATA analysis
MULTIPLE regression analysis
CROSS-sectional method
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
DISEASE complications
PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 09607439
- Volume :
- 26
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of Paediatric Dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 111998447
- Full Text :
- https://doi.org/10.1111/ipd.12156