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Anemia in children following renal transplantation-results from the ESPN/ERA-EDTA Registry.

Authors :
Krischock, Leah
Stralen, Karlijn
Verrina, Enrico
Tizard, E.
Bonthuis, Marjolein
Reusz, György
Hussain, Farida
Jankauskiene, Augustina
Novljan, Gregor
Spasojević-Dimitrijeva, Brankica
Podracka, Ludmila
Zaller, Vera
Jager, Kitty
Schaefer, Franz
Source :
Pediatric Nephrology; Feb2016, Vol. 31 Issue 2, p325-333, 9p, 3 Charts, 3 Graphs
Publication Year :
2016

Abstract

Background: Our aim was to determine the prevalence of sub-target hemoglobin (Hb) levels in children with a renal allograft and to identify potential determinants associated with these Hb levels. Methods: Data from 3669 children with a functioning renal allograft, aged <18 years between 1 January 2000 and 31 December 2012, from 20 European countries were retrieved from the ESPN/ERA-EDTA Registry, providing 16,170 Hb measurements. Results: According to the NKF/KDOQI classification and the UK-NICE guidelines, 49.8 and 7.8 % of the patients, respectively, were anemic. Hb levels were strongly associated with graft function, with Hb levels of 12.6 g/dl in children with chronic kidney disease (CKD) stage 1, declining to 10.7 g/dl in children with CKD stage 5 ( P < 0.001). Higher Hb levels were associated with the use of tacrolimus compared to ciclosporin (0.14 g/dl; 95 % confidence interval 0.02-0.27; P = 0.002). Low Hb levels were associated with an increased risk of graft failure ( P = 0.01) or combined graft failure and death ( P < 0.01), but not with death alone (not significant). Conclusions: Anemia is present in a significant proportion of European pediatric kidney transplant recipients and is associated with renal allograft dysfunction and type of immunosuppressants used. In our patient cohort, higher Hb levels were associated with better graft and patient survival and less hypertension. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0931041X
Volume :
31
Issue :
2
Database :
Complementary Index
Journal :
Pediatric Nephrology
Publication Type :
Academic Journal
Accession number :
111968571
Full Text :
https://doi.org/10.1007/s00467-015-3201-8