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Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population.
- Source :
- Journal of the Renin-Angiotensin-Aldosterone System; Dec2015, Vol. 16 Issue 4, p880-887, 8p
- Publication Year :
- 2015
-
Abstract
- <bold>Hypothesis: </bold>Polymorphisms in angiotensin II type-1/2 receptor genes (AGTR1/AGTR2) may be involved in the pathogenesis of primary aldosteronism. The present study aims to reveal some loci susceptible to the disease on the genes in a group of Chinese Han nationality.<bold>Materials and Methods: </bold>A case-control study was conducted in 202 patients and 188 controls. Ten tagging SNPs on AGTR1/AGTR2 were genotyped for all subjects via the method of multiplex PCR-ligase detection reaction. Statistical analysis was performed with chi-square test and logistic regression analysis.<bold>Results: </bold>rs3772616 on the AGTR1 gene was a factor for susceptibility to primary aldosteronism (p<0.001), and the TT genotype significantly decreased the risk of primary aldosteronism compared with the CC homozygote (p=0.008, adjusted OR=0.13; 95%CI: 0.03-0.59). The rs3772616 polymorphism was associated with primary aldosteronism under the additive and dominant models. The female carriers of the G allele in rs5193 showed a significant difference compared with the T allele.<bold>Conclusions: </bold>The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14703203
- Volume :
- 16
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of the Renin-Angiotensin-Aldosterone System
- Publication Type :
- Academic Journal
- Accession number :
- 111957677
- Full Text :
- https://doi.org/10.1177/1470320314534511