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The anticancer agent methyl jasmonate induces activation of stress-regulated c-Jun N-terminal kinase and p38 protein kinase in human lymphoid cells.

Authors :
Rotem, R.
Fingrut, O.
Moskovitz, J.
Flescher, E.
Source :
Leukemia (08876924); Nov2003, Vol. 17 Issue 11, p2230-2234, 5p
Publication Year :
2003

Abstract

Cites findings of a study which reveals that plant stress hormones are capable of suppressing apoptosis in various transformed human cells including leukemia, melanoma, prostate and breast cell cancer. Revelation that methyl jasmonate (MJ) was determined to be the most potent agent in suppressing apoptosis; Information that MJ killed Molt-4 human lymphoblastic leukemia cells in efficient manner; Observation that MJ did not affect normal human peripheral blood lymphocytes; Details of methodology adopted for the study to assess the effectiveness of MJ against lymphoblastic leukemia cells.

Details

Language :
English
ISSN :
08876924
Volume :
17
Issue :
11
Database :
Complementary Index
Journal :
Leukemia (08876924)
Publication Type :
Academic Journal
Accession number :
11189671
Full Text :
https://doi.org/10.1038/sj.leu.2403107