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The anticancer agent methyl jasmonate induces activation of stress-regulated c-Jun N-terminal kinase and p38 protein kinase in human lymphoid cells.
- Source :
- Leukemia (08876924); Nov2003, Vol. 17 Issue 11, p2230-2234, 5p
- Publication Year :
- 2003
-
Abstract
- Cites findings of a study which reveals that plant stress hormones are capable of suppressing apoptosis in various transformed human cells including leukemia, melanoma, prostate and breast cell cancer. Revelation that methyl jasmonate (MJ) was determined to be the most potent agent in suppressing apoptosis; Information that MJ killed Molt-4 human lymphoblastic leukemia cells in efficient manner; Observation that MJ did not affect normal human peripheral blood lymphocytes; Details of methodology adopted for the study to assess the effectiveness of MJ against lymphoblastic leukemia cells.
- Subjects :
- CANCER prevention
APOPTOSIS
PLANT hormones
LYMPHOBLASTIC leukemia treatment
RESEARCH
PROTEIN metabolism
NUCLEOTIDE metabolism
ACETIC acid
BINDING sites
COMPARATIVE studies
DYNAMICS
ENZYME inhibitors
GROWTH factors
HYDROCARBONS
LYMPHOCYTIC leukemia
RESEARCH methodology
MEDICAL cooperation
NUCLEOTIDES
PHOSPHORYLATION
PIPERIDINE
TRANSFERASES
UNSATURATED fatty acids
EVALUATION research
CANCER cell culture
DACTINOMYCIN
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Volume :
- 17
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Leukemia (08876924)
- Publication Type :
- Academic Journal
- Accession number :
- 11189671
- Full Text :
- https://doi.org/10.1038/sj.leu.2403107