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Predicted vitamin D status during pregnancy in relation to offspring forearm fractures in childhood: a study from the Danish National Birth Cohort.
- Source :
- British Journal of Nutrition; 12/14/2015, Vol. 114 Issue 11, p1900-1908, 9p
- Publication Year :
- 2015
-
Abstract
- In a prospective cohort study, the association between maternal vitamin D status during pregnancy and offspring forearm fractures during childhood and adolescence was analysed in 30 132 mother and child pairs recruited to the Danish National Birth Cohort between 1996 and 2002. Data on characteristics, dietary factors and lifestyle factors were collected on several occasions during pregnancy. We analysed the association between predicted vitamin D status, based on a subsample with 25-hydroxyvitamin D (25(OH)D) biomarker measurements (n 1497) from gestation week 25, and first-time forearm fractures among offspring between birth and end of follow-up. Diagnoses were extracted from the Danish National Patient Register. Multivariable Cox regression models using age as the underlying time scale indicated no overall association between predicted vitamin D status (based on smoking, season, dietary and supplementary vitamin D intake, tanning bed use and outdoor physical activity) in pregnancy and offspring forearm fractures. Likewise, measured 25(OH)D, tanning bed use and dietary vitamin D intake were not associated with offspring forearm fractures. In mid-pregnancy, 91 % of the women reported intake of vitamin D from dietary supplements. Offspring of women who took >10 µg/d in mid-pregnancy had a significantly increased risk for fractures compared with the reference level of zero intake (hazard ratios (HR) 1·31; 95 % CI 1·06, 1·62), but this was solely among girls (HR 1·48; 95 % CI 1·10, 2·00). Supplement use in the peri-conceptional period exhibited similar pattern, although not statistically significant. In conclusion, our data indicated no protective effect of maternal vitamin D status with respect to offspring forearm fractures. [ABSTRACT FROM PUBLISHER]
- Subjects :
- CHI-squared test
CONFIDENCE intervals
DIETARY supplements
BONE fractures
LONGITUDINAL method
MOTHERS
NUTRITIONAL requirements
POPULATION geography
PREGNANT women
QUESTIONNAIRES
RADIUS bone injuries
REGRESSION analysis
RESEARCH funding
VITAMIN D
ULNA injuries
PROPORTIONAL hazards models
DATA analysis software
DESCRIPTIVE statistics
KAPLAN-Meier estimator
CHILDREN
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 114
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- British Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 110756260
- Full Text :
- https://doi.org/10.1017/S000711451500361X