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Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and γ-Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level.
- Source :
- Alcoholism: Clinical & Experimental Research; Nov2015, Vol. 39 Issue 11, p2200-2208, 9p
- Publication Year :
- 2015
-
Abstract
- Background In clinical practice as well as research situations, it is of great importance to get reliable information about a patient's alcohol consumption. The aim of the study was to investigate the correlation of alcohol biomarkers (phosphatidylethanol [PEth], carbohydrate-deficient transferrin [ CDT], γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase) to retrospective as well as diary-based alcohol self-reports and to examine whether it is possible to correlate a biomarker result to a more precise level of alcohol consumption. Methods One hundred and sixty alcohol-dependent patients were included in a randomized, placebo-controlled clinical trial of pharmacotherapy for alcohol dependence, of which 115 (76 men and 39 women) completed the study. Retrospective alcohol consumption data were collected at baseline, and alcohol diaries were used during the study. Blood samples for determination of alcohol biomarkers were collected on 5 occasions during the study. Results PEth and CDT showed a better correlation with alcohol consumption documented in the diary ( PEth r<subscript>s</subscript> = 0.56 and CDT r<subscript>s</subscript> = 0.35) than with retrospective consumption data ( PEth r<subscript>s</subscript> = 0.23 and CDT r<subscript>s</subscript> = 0.22). An even higher correlation ( r<subscript>s</subscript> = 0.63) was seen between the 2 alcohol biomarkers PEth and CDT. At all consumption levels, PEth had the highest sensitivity of all biomarkers studied. Conclusions PEth was the biomarker with the best correlation to self-reported alcohol consumption. PEth was superior to CDT owing to its substantially higher sensitivity but also due to its closer correlation to self-report. PEth values can be translated into an approximate level of alcohol consumption and PEth appears to be a more reliable measure of alcohol consumption than self-reports. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLACEBOS
NICOTINIC agonists
PHOSPHOLIPID analysis
ALCOHOLISM
ASPARTATE aminotransferase
BIOMARKERS
ALCOHOL drinking
MEDICAL cooperation
REGRESSION analysis
RESEARCH
RESEARCH funding
STATISTICS
TRANSFERRIN
DATA analysis
ALANINE aminotransferase
RANDOMIZED controlled trials
RETROSPECTIVE studies
DATA analysis software
DIARY (Literary form)
DESCRIPTIVE statistics
GAMMA-glutamyltransferase
MANN Whitney U Test
THERAPEUTICS
Subjects
Details
- Language :
- English
- Volume :
- 39
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Alcoholism: Clinical & Experimental Research
- Publication Type :
- Academic Journal
- Accession number :
- 110546923
- Full Text :
- https://doi.org/10.1111/acer.12883