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Vitamin D status is associated with cardiometabolic markers in 8–11-year-old children, independently of body fat and physical activity.
- Source :
- British Journal of Nutrition; 11/28/2015, Vol. 114 Issue 10, p1647-1655, 9p
- Publication Year :
- 2015
-
Abstract
- Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8–11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August–November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (−0·3 mmHg, 95 % CI −0·6, −0·0) (P=0·02), total cholesterol (−0·07 mmol/l, 95 % CI −0·10, −0·05), LDL-cholesterol (−0·05 mmol/l, 95 % CI −0·08, −0·03), TAG (−0·02 mmol/l, 95 % CI −0·03, −0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause–effect relationship and possible long-term implications should be investigated in randomised controlled trials. [ABSTRACT FROM PUBLISHER]
- Subjects :
- BLOOD sugar analysis
ADIPOSE tissues
BLOOD pressure
BODY composition
BODY weight
CARDIOVASCULAR diseases
CHI-squared test
CHOLESTEROL
CONFIDENCE intervals
DEMOGRAPHY
FISHER exact test
HEART beat
HIGH density lipoproteins
INSULIN resistance
INTERLEUKINS
INTERVIEWING
LOW density lipoproteins
PARATHYROID hormone
PROBABILITY theory
RESEARCH funding
STATURE
T-test (Statistics)
VITAMIN D
LOGISTIC regression analysis
METABOLIC syndrome
BODY mass index
ACCELEROMETRY
CROSS-sectional method
FOOD diaries
PHYSICAL activity
DATA analysis software
ADIPONECTIN
WAIST circumference
DESCRIPTIVE statistics
NUTRITIONAL status
MANN Whitney U Test
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 114
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- British Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 110459712
- Full Text :
- https://doi.org/10.1017/S0007114515003372