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Clear cell hepatocellular carcinoma: Back to the basics for diagnosis.
- Source :
- Journal of Cancer Research & Therapeutics; Jul-Sep2015, Vol. 11 Issue 3, Special section p656-656, 3p
- Publication Year :
- 2015
-
Abstract
- Hepatocellular carcinoma (HCC) is a common cancer world-wide with a higher incidence in Asia. Clear cell variant of HCC (CCHCC) has a frequency ranging from 0.4% to 37%. The presence of 90-100% clear cells is rare. In the present case, a 35-year-old female patient presented with fever and a large abdominal mass in the right hypochondrium. Histology of the tumor revealed >95% clear cells and after taking multiple sections from different areas of tumor only few scattered cells with eosinophilic cytoplasm were found. Immunohistochemistry with Hep Par 1, Glypican 3 and polyclonal carcinoembryonic antigen were negative as were all other markers for metastatic clear cell tumors. Histological diagnosis was based on routine H and E sections showing a histological pattern of architecture with thickened trabeculae. We describe a rare case of CCHCC with >95% clear cells and no immunoreactivity in tumor cells in a non-cirrhotic liver. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09731482
- Volume :
- 11
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Cancer Research & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 110396093
- Full Text :
- https://doi.org/10.4103/0973-1482.136041