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Recent progress in the development of anti-malarial quinolones.

Authors :
Beteck, Richard M.
Smit, Frans J.
Haynes, Richard K.
N’Da, David D.
Source :
Malaria Journal; 2014, Vol. 13 Issue 1, p339-348, 10p, 8 Diagrams
Publication Year :
2014

Abstract

Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people now die from malaria, emerging resistance to the first-line anti-malarial drugs, namely artemisinins in combination with quinolines and arylmethanols, necessitates the urgent development of new anti-malarial drugs to curb the disease. The quinolones are a promising class of compounds, with some demonstrating potent in vitro activity against the malaria parasite. This review summarizes the progress made in the development of potential anti-malarial quinolones since 2008. The efficacy of these compounds against both asexual blood stages and other stages of the malaria parasite, the nature of putative targets, and a comparison of these properties with anti-malarial drugs currently in clinical use, are discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14752875
Volume :
13
Issue :
1
Database :
Complementary Index
Journal :
Malaria Journal
Publication Type :
Academic Journal
Accession number :
110244341
Full Text :
https://doi.org/10.1186/1475-2875-13-339