Back to Search
Start Over
Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA.
- Source :
- Environmental Health Perspectives; Oct2015, Vol. 123 Issue 10, p1079-1085, 7p, 3 Charts, 1 Graph
- Publication Year :
- 2015
-
Abstract
- BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera. METHODS: We used data from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort of 389 pregnant women in Cincinnati, Ohio, who were enrolled from 2003 through 2006 and delivered singleton infants. Maternal serum PBDE concentrations were measured at enrollment (16 ±3 weeks of gestation). Thyroid hormone concentrations were measured in maternal serum at enrollment (n = 187) and in cord serum samples (n = 256). RESULTS: Median maternal serum concentrations of BDEs 28 and 47 were 1.0 and 19.1 ng/g lipid, respectively. A 10-fold increase in BDEs 28 and 47 concentrations was associated with a 0.85-μg/dL [95% confidence interval (CI): 0.05, 1.64] and 0.82-μg/dL (95% CI: 0.12, 1.51) increase in maternal total thyroxine concentrations (TT<subscript>4</subscript>), respectively. Both congeners were also positively associated with maternal free thyroxine (FT<subscript>4</subscript>). We also observed positive associations between BDE-47 and maternal total and free triiodothyronine (TT<subscript>3</subscript> and FT<subscript>3</subscript>). A 10-fold increase in BDE-28 was associated with elevated FT<subscript>3</subscript> concentrations (β = 0.14 pg/mL; 95% CI: 0.02, 0.26). In contrast, maternal PBDE levels were not associated with thyroid hormone concentrations in cord serum. CONCLUSIONS: These findings suggest that maternal PBDE exposure, particularly BDEs 28 and 47, are associated with maternal concentrations of T<subscript>4</subscript> and T<subscript>3</subscript> during pregnancy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 123
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 110128888
- Full Text :
- https://doi.org/10.1289/ehp.1408996