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Hepatitis B Surface Antigen Quantification across Different Phases of Chronic Hepatitis B Virus Infection Using an Immunoradiometric Assay.
- Source :
- Gut & Liver; Sep2015, Vol. 9 Issue 5, p657-664, 8p
- Publication Year :
- 2015
-
Abstract
- Background/Aims: Quantification of hepatitis B surface antigen (HBsAg) is an emerging serologic test and may be useful for identifying treatment strategies for chronic hepatitis B (CHB). This study aimed to evaluate HBsAg titers during the natural course of CHB and identify correlations between HBsAg titers and hepatitis B virus (HBV) DNA concentrations across different CHB phases measured using an immunoradiometric assay (IRMA). Methods: CHB phases were defined on the basis of HBV DNA concentrations, the presence of hepatitis B e antigen/antibody (HBeAg/Ab) and serum alanine aminotransferase levels. Serum HBsAg titers and paired HBV DNA concentrations in the different phases of CHB were compared using 627 serum samples. Results: Mean HBsAg titers were significantly higher in the immunotolerant (IT) phase and immunoreactive (IR) HBeAg-positive phase than in the low-replicative (LR) and HBeAg-negative CHB (ENH) states. The correlation between HBsAg titers and HBV DNA concentrations was modest in the IT (n=36, r=0.804, p<0.001) and IR (n=48, r=0.773, p<0.001) phases, and it was poor in the LR state (n=116, r=0.289, p=0.002); however, no significant correlation was observed in the ENH state (n=67, r=0.146, p=0.237) or in the oral nucleos(t)ide analogue-treated group (n=267). Conclusions: HBsAg quantification using IRMA might be useful for discriminating different CHB phases and different stages of chronic liver disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATITIS B
ANTIGENS
CELL surface antigens
HEPATITIS B virus
AMINOTRANSFERASES
Subjects
Details
- Language :
- English
- ISSN :
- 19762283
- Volume :
- 9
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Gut & Liver
- Publication Type :
- Academic Journal
- Accession number :
- 110114182
- Full Text :
- https://doi.org/10.5009/gnl14188