Three-Component Reaction of Pyrimidin-2-yl Sulfonates with Sodium Azide and Alkynes: An Efficient Approach to C2-Triazolo Functionalized Pyrimidines.

Pyrimidin-2-yl sulfonate, as an efficient reaction partner, can be easily prepared from cheap commercial materials, reacted with sodium azide and alkynes to give C2-triazolo functionalized pyrimidines in good yields under mild reaction conditions. This procedure eliminates the need to handle organic halides or organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe. [ABSTRACT FROM AUTHOR]