Back to Search
Start Over
Lipoarabinomannan-specific TNF-α and IFN-γ as markers of protective immunity against tuberculosis: a cohort study in an endemic setting.
- Source :
- APMIS; Oct2015, Vol. 123 Issue 10, p851-857, 7p
- Publication Year :
- 2015
-
Abstract
- Lipoarabinomannan ( LAM) is a virulent factor used for entry and survival of Mycobacterium tuberculosis ( Mtb) in macrophages. Although the role of LAM for the diagnosis of tuberculosis ( TB) has been extensively investigated, its cytokine response during natural Mtb infection in humans is largely unknown. In this study, LAM-specific IFN-γ, TNF-α, and IL-10 levels following whole blood assay were measured in untreated pulmonary TB patients, their contacts and community controls at baseline. In treated patients and contacts, cytokines were also measured at 6 and 12 months. At entry, 52.8% and 74.8% of controls and contacts were QFT- GIT positive, respectively. At baseline, untreated TB patients and contacts had significantly lower IFN-γ and TNF-α response compared to community controls (p < 0.0001). Besides, untreated patients had significantly higher TNF-α and IL-10 response compared to their contacts (p < 0.0001). At 6 months, contacts and treated TB patients had significantly increased INF-γ and TNF-α response (p < 0.0001). In TB patients, IFN-γ increased 10-fold following chemotherapy suggesting its potential role for treatment monitoring. The data suggests that LAM might have an anti-inflammatory effect during clinical TB and early Mtb infection. The data also suggests that LAM-induced IFN-γ and TNF-α could be used as biomarkers of protective immunity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09034641
- Volume :
- 123
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- APMIS
- Publication Type :
- Academic Journal
- Accession number :
- 109992443
- Full Text :
- https://doi.org/10.1111/apm.12423