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Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
- Source :
- Retrovirology; 9/27/2015, Vol. 12 Issue 1, p1-5, 5p
- Publication Year :
- 2015
-
Abstract
- Background: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. Findings: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. Conclusions: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers. [ABSTRACT FROM AUTHOR]
- Subjects :
- VACCINES
ANTIGENS
B cells
FERRITIN
GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 12
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 109978501
- Full Text :
- https://doi.org/10.1186/s12977-015-0210-4