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RXFP1 is targeted by complement C1q tumor necrosis factor-related factor 8 in brain cancer.
- Source :
- Frontiers in Endocrinology; Aug2015, p1-6, 6p
- Publication Year :
- 2015
-
Abstract
- The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- TUMOR necrosis factors
RELAXIN
BRAIN cancer
GENETICS
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Database :
- Complementary Index
- Journal :
- Frontiers in Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 109951138
- Full Text :
- https://doi.org/10.3389/fendo.2015.00127