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Resveratrol plus carboxymethyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis.
- Source :
- Current Medical Research & Opinion; Oct2014, Vol. 30 Issue 10, p1931-1935, 5p
- Publication Year :
- 2014
-
Abstract
- <bold>Objective: </bold>Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction consequent to the exposure to causal allergen. Resveratrol is a natural non-flavonoid polyphenol, exerting anti-inflammatory activity; β-glucan is a polysaccharide with immuno-modulatory properties. Thus, this study aimed to investigate whether these combined compounds are able of relieving nasal symptoms in children with AR due to pollen allergy.<bold>Research Design and Methods: </bold>The present study was conducted as placebo-controlled, double-blinded, and randomized. Globally, 68 children (36 males; mean age 7.9 years) were treated with resveratrol plus β-glucan or placebo (the diluent of active drug) two sprays (100 µL/spray) in each nostril three times/day for 2 months. Nasal symptoms, including itching, sneezing, rhinorrhea, and obstruction, were assessed at baseline and after treatment. Use of rescue medication, such as cetirizine syrup, was also evaluated.<bold>Clinical Trial Registration: </bold>ClinicalTrials.gov ID NCT02130440.<bold>Results: </bold>Children treated with active drug achieved a significant reduction in all nasal symptoms: itching (p = 0.0001), sneezing (p = 0.0009), rhinorrhea (p = 0.009), and obstruction (0.002) as well as antihistamine use (p = 0.003). Placebo did not affect nasal complaints and cetirizine use. The intergroup analysis showed that active treatment was significantly superior to placebo about reduction of AR symptoms and rescue medication use.<bold>Conclusions: </bold>The present preliminary study firstly showed that intranasal resveratrol plus carboxymethyl-β-glucan is capable of significantly improving nasal symptoms in children with pollen-induced AR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03007995
- Volume :
- 30
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Current Medical Research & Opinion
- Publication Type :
- Academic Journal
- Accession number :
- 109756689
- Full Text :
- https://doi.org/10.1185/03007995.2014.938731