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Resveratrol plus carboxymethyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis.

Authors :
Miraglia Del Giudice, Michele
Maiello, Nunzia
Capristo, Carlo
Alterio, Emilia
Capasso, Michele
Perrone, Laura
Ciprandi, Giorgio
Source :
Current Medical Research & Opinion; Oct2014, Vol. 30 Issue 10, p1931-1935, 5p
Publication Year :
2014

Abstract

<bold>Objective: </bold>Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction consequent to the exposure to causal allergen. Resveratrol is a natural non-flavonoid polyphenol, exerting anti-inflammatory activity; β-glucan is a polysaccharide with immuno-modulatory properties. Thus, this study aimed to investigate whether these combined compounds are able of relieving nasal symptoms in children with AR due to pollen allergy.<bold>Research Design and Methods: </bold>The present study was conducted as placebo-controlled, double-blinded, and randomized. Globally, 68 children (36 males; mean age 7.9 years) were treated with resveratrol plus β-glucan or placebo (the diluent of active drug) two sprays (100 µL/spray) in each nostril three times/day for 2 months. Nasal symptoms, including itching, sneezing, rhinorrhea, and obstruction, were assessed at baseline and after treatment. Use of rescue medication, such as cetirizine syrup, was also evaluated.<bold>Clinical Trial Registration: </bold>ClinicalTrials.gov ID NCT02130440.<bold>Results: </bold>Children treated with active drug achieved a significant reduction in all nasal symptoms: itching (p = 0.0001), sneezing (p = 0.0009), rhinorrhea (p = 0.009), and obstruction (0.002) as well as antihistamine use (p = 0.003). Placebo did not affect nasal complaints and cetirizine use. The intergroup analysis showed that active treatment was significantly superior to placebo about reduction of AR symptoms and rescue medication use.<bold>Conclusions: </bold>The present preliminary study firstly showed that intranasal resveratrol plus carboxymethyl-β-glucan is capable of significantly improving nasal symptoms in children with pollen-induced AR. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03007995
Volume :
30
Issue :
10
Database :
Complementary Index
Journal :
Current Medical Research & Opinion
Publication Type :
Academic Journal
Accession number :
109756689
Full Text :
https://doi.org/10.1185/03007995.2014.938731