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Innate immunological function of TH2 cells in vivo.
- Source :
- Nature Immunology; Oct2015, Vol. 16 Issue 10, p1051-1059, 9p, 7 Graphs
- Publication Year :
- 2015
-
Abstract
- Type 2 helper T cells (T<subscript>H</subscript>2 cells) produce interleukin 13 (IL-13) when stimulated by papain or house dust mite extract (HDM) and induce eosinophilic inflammation. This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs). While type 2 innate lymphoid cells (ILC2 cells) are the dominant innate producers of IL-13 in naive mice, we found here that helminth-infected mice had more T<subscript>H</subscript>2 cells compared to uninfected mice, and thes e cells became major mediators of innate type 2 responses. T<subscript>H</subscript>2 cells made important contributions to HDM-induced antigen-nonspecific eosinophilic inflammation and protected mice recovering from infection with Ascaris suum against subsequent infection with the phylogenetically distant nematode Nippostrongylus brasiliensis. Our findings reveal a previously unappreciated role for effector T<subscript>H</subscript>2 cells during TCR-independent innate-like immune responses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 16
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 109508019
- Full Text :
- https://doi.org/10.1038/ni.3244