Back to Search
Start Over
Feasibility study and pilot randomised trial of an antenatal depression treatment with infant follow-up.
- Source :
- Archives of Women's Mental Health; Oct2015, Vol. 18 Issue 5, p717-730, 14p, 2 Diagrams, 5 Charts
- Publication Year :
- 2015
-
Abstract
- Substantial evidence links antenatal depression, anxiety and stress with negative effects on foetal development, resulting in enduring problems in child development. Despite this, there is a paucity of research on intervention programmes designed to address depression and anxiety, and none that include infant outcomes. We aimed to evaluate the efficacy of a brief treatment for maternal depression and anxiety in pregnancy in a sample of women with a diagnosed depressive disorder. We developed a cognitive behavioural therapy treatment for antenatal depression and anxiety and evaluated it in a feasibility trial. This was followed by a pilot randomised controlled trial (RCT) which collected data on the efficacy of the brief intervention and follow-up data on infants. The feasibility study ( n = 25) yielded promising results for adherence, acceptability and improvements in depression and anxiety (Beck Depression Inventory and Beck Anxiety Inventory). The RCT ( n = 54) again showed excellent adherence and acceptability and supported the efficacy of the treatment. Strong reductions in anxiety were observed during pregnancy, and improvements in depression were maintained at 9 months representing a moderately large effect size. Nine-month infant outcomes showed several medium to large effects favouring the intervention in domains including problem solving, self-regulation and stress reactivity, which were independent of maternal postnatal mood. Treating severe depression and anxiety during pregnancy with a brief cognitive behavioural therapy (CBT) intervention appears feasible and worthwhile. To reliably detect clinically meaningful effects on infant outcomes, larger RCTs are likely to be required. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREVENTION of mental depression
MENTAL depression
THERAPEUTICS
BRIEF psychotherapy
COGNITIVE therapy
CONFIDENCE intervals
INFANT development
PRENATAL care
PROBABILITY theory
PSYCHOLOGICAL tests
QUESTIONNAIRES
RESEARCH funding
SELF-evaluation
STATISTICS
T-test (Statistics)
LOGISTIC regression analysis
PILOT projects
EDINBURGH Postnatal Depression Scale
EFFECT sizes (Statistics)
RANDOMIZED controlled trials
TREATMENT effectiveness
PRE-tests & post-tests
MAXIMUM likelihood statistics
DATA analysis software
DESCRIPTIVE statistics
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 14341816
- Volume :
- 18
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Archives of Women's Mental Health
- Publication Type :
- Academic Journal
- Accession number :
- 109323501
- Full Text :
- https://doi.org/10.1007/s00737-015-0512-5