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Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity.

Authors :
Tang, Hao
Dong, Ze-Xi
Gu, Ting
Li, Nian-Guang
Tang, Yu-Ping
Shi, Qian-Ping
Guo, Jian-Ming
Zhang, Peng-Xuan
Duan, Jin-Ao
Source :
Journal of Chemistry; 6/7/2015, Vol. 2015, p1-7, 7p
Publication Year :
2015

Abstract

Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca<superscript>2+</superscript> concentration together with Ca<superscript>2+</superscript>-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca<superscript>2+</superscript> level, and improving Ca<superscript>2+</superscript>-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20909063
Volume :
2015
Database :
Complementary Index
Journal :
Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
109206818
Full Text :
https://doi.org/10.1155/2015/497842