Stone Particle-induced Interleukin-6 and -8 Release Involves Activation of MAP Kinases and Tyrosine Kinases.

PM₁₀ fractions of four different stone particles used in road pavement (mylonite, gabbro, basalt and feldspar) were shown to induce a significant increase in interleukin-6 and -8 release from A549 cells. Inhibition of MAP kinases p38 and ERK, as well as inhibition of tyrosine kinases, resulted in inhibition of mylonite-induced cytokine release. Preliminary results with the three most potent particles tested, supports the inhibition pattern shown with mylonite. [ABSTRACT FROM AUTHOR]