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Effects of low-dose milnacipran on event-related potentials and neuropsychological tests in persons with traumatic brain injury: A preliminary study.
- Source :
- Brain Injury; Sep2015, Vol. 29 Issue 10, p1252-1257, 6p
- Publication Year :
- 2015
-
Abstract
- Introduction: Psychostimulants are among the most commonly used pharmacological agents for countering cognitive dysfunction and/or enhancing rehabilitation in persons with brain injury. It was postulated that milnacipran, a serotonin-norepinephrine reuptake inhibitor, would be effective against cognitive dysfunction in non-depressed persons with brain injury. Methods: Eighteen patients were recruited with at least moderate disability more than 4 months after a traumatic brain injury (TBI) and they were randomized to an 8-week, placebo-controlled, double-blind trial. Cognitive dysfunction was assessed at baseline with the Trail Making Test, the Wechsler Adult Intelligence Scale-Revised (WAIS-R), the Wechsler Memory Scale-Revised (WMS-R) and measurement of event-related potentials (ERPs) both before randomization and after an 8-week administration of milnacipran or placebo. Results: N2 and P3 latencies in the milnacipran group were significantly shortened by the intervention. Moreover, the Verbal Intelligence Quotient and Full Intelligence Quotient scores of the WAIS-R and the delayed recall score of the WMS-R were significantly higher than baseline after milnacipran intervention. Conclusion: Milnacipran administration improved ERP measures of attention and information processing in non-depressed persons with brain injury and also improved scores on three sub-scales of standard neuropsychological tests of cognitive dysfunction. Therefore, this intervention merits validation by additional, larger studies. [ABSTRACT FROM PUBLISHER]
- Subjects :
- COGNITION disorders diagnosis
ACADEMIC medical centers
ATTENTION
BRAIN injuries
COGNITION
COMPARATIVE studies
MENTAL depression
DOSE-effect relationship in pharmacology
ELECTROENCEPHALOGRAPHY
ELECTROOCULOGRAPHY
EVOKED potentials (Electrophysiology)
INTELLIGENCE tests
INTERVIEWING
MAGNETIC resonance imaging
NEUROPSYCHOLOGICAL tests
MEMORY
PROBABILITY theory
REHABILITATION centers
RESEARCH funding
SELF-report inventories
SEROTONIN uptake inhibitors
STATISTICS
WECHSLER Adult Intelligence Scale
PILOT projects
DATA analysis
RANDOMIZED controlled trials
BLIND experiment
ADRENERGIC uptake inhibitors
DATA analysis software
DESCRIPTIVE statistics
MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 02699052
- Volume :
- 29
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Brain Injury
- Publication Type :
- Academic Journal
- Accession number :
- 108975757
- Full Text :
- https://doi.org/10.3109/02699052.2015.1035332