Analysis of interactions of lipid metabolism alleles in dyslipidemia.

The parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) can be manifested as elevated levels of total cholesterol and triglycerides or as changes in other indices resulting from aberrations in the lipoprotein synthesis, transport or cleavage. The clinical importance of a range of metabolic disorders, defined overall as dyslipidemia, is associated primarily with a high risk of cardiovascular disease, diabetes mellitus type 2, and obesity. Here, we examined the association of certain SNPs ( G2548A in the promoter region of leptin gene LEP; A223G, in the exon 4 of leptin receptor gene LEPR; T495G, in the intron 8 in lipoprotein lipase gene LPL; and C34G, in exon 8 of the peroxisome proliferator-activated nuclear receptor γ PPARG) with disruptions in lipid metabolism; and we demonstrated their cumulative contribution towards the development of dyslipidemia. [ABSTRACT FROM AUTHOR]