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Antiviral glycosidic bisindole alkaloids from the roots of Isatis indigotica.
- Source :
- Journal of Asian Natural Products Research; Jul2015, Vol. 17 Issue 7, p689-704, 16p
- Publication Year :
- 2015
-
Abstract
- Seven new glycosidic bisindole alkaloids, isatindigobisindolosides A–G (1–7), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including absolute configurations were determined by spectroscopic and chemical methods, together with calculations of electronic circular dichroism (ECD) spectra based on the quantum-mechanical time-dependent density functional theory. In the NMR spectra of 1–3, it is found that integration of H-2 and intensity of C-2 are affected not only by a substitution group at C-2 but also by solvents. Influences of the glucopyranosyloxy on the calculated ECD spectra of the glycosidic bisindole alkaloids are discussed. Compounds 2, 5, and 6 showed antiviral activity against both the influenza virus A/Hanfang/359/95 (H3N2) and Coxsackie virus B3 with IC<subscript>50</subscript> values of 8.4–100.0 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALKALOIDS
ANTIVIRAL agents
BIOLOGICAL assay
CHROMATOGRAPHIC analysis
COXSACKIEVIRUSES
GLYCOSIDES
INFRARED spectroscopy
MASS spectrometry
INFLUENZA A virus, H3N2 subtype
MOLECULAR structure
NUCLEAR magnetic resonance spectroscopy
RESEARCH funding
RIBAVIRIN
PLANT roots
DATA analysis software
IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 17
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 108756188
- Full Text :
- https://doi.org/10.1080/10286020.2015.1055729