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Comprehensive Proteome Analysis of the Excretory/Secretory Proteins of Toxoplasma gondii.
- Source :
- Bulletin of the Korean Chemical Society; 2014, Vol. 35 Issue 10, p3070-3076, 6p
- Publication Year :
- 2014
-
Abstract
- Proteomic analyses of the excretory/secretory proteins from the RH strain of Toxoplasma gondii have been performed to understand their functions in the host-parasite interaction. A total of 34 proteins were identified from LC/MS/MS analysis and their abundance was estimated by spectral counting methods. Among them, 8 species of micronemal proteins (MICs), 2 species of rhoptry proteins (ROPs), and 6 species of dense granular proteins (GRAs) were confirmed. Besides these, 18 species of protein were newly identified, and their cellular functions were estimated from sequence analysis. The three most abundant of the 34 identified extractor/secretory proteins GRA1, GRA7 and GRA2 were confirmed to be highly expressed in T. gondii using the spectral count method. This phenomenon is another demonstration of the importance of GRA proteins for the penetration and survival of T. gondii. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEOMICS
TOXOPLASMA gondii
PROTEINS
SEQUENCE analysis
MOLECULAR biology
Subjects
Details
- Language :
- English
- ISSN :
- 02532964
- Volume :
- 35
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Bulletin of the Korean Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 108750438
- Full Text :
- https://doi.org/10.5012/bkcs.2014.35.10.3071