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NF-κB Activation and PPAR Transactivational Effects of a New Aliphatic Acid Amide from Pericarps of Zanthoxylum piperitum.
- Source :
- Bulletin of the Korean Chemical Society; 2014, Vol. 35 Issue 8, p2361-2366, 6p
- Publication Year :
- 2014
-
Abstract
- A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (-)- sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on TNFα-induced NF-τB activation and transactivational activity of PPARs, including PPARα, PPARβ(δ) and PPARγ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on TNFα-induced NF-τB activation with IC50 values of 5.50 and 8.10 μM, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with EC50 values of 47.12, 19.13 and 12.02 μM, respectively. Among them, compound 4 demonstrated an increase in PPARα transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALIPHATIC compounds
ZANTHOXYLUM
PERICARP
SESAMIN
AMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 02532964
- Volume :
- 35
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Bulletin of the Korean Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 108750230
- Full Text :
- https://doi.org/10.5012/bkcs.2014.35.8.2361