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RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63.

Authors :
Warshauer, Emily
Samuelov, Liat
Sarig, Ofer
Vodo, Dan
Bindereif, Albrecht
Kanaan, Moien
Gat, Uri
Fuchs‐Telem, Dana
Shomron, Noam
Farberov, Luba
Pasmanik‐Chor, Metsada
Nardini, Gil
Winkler, Eyal
Meilik, Benjamin
Petit, Isabelle
Aberdam, Daniel
Paus, Ralf
Sprecher, Eli
Nousbeck, Janna
Source :
Experimental Dermatology; Aug2015, Vol. 24 Issue 8, p618-622, 5p
Publication Year :
2015

Abstract

Alopecia-neurological defects-endocrinopathy ( ANE) syndrome is a rare inherited hair disorder, which was shown to result from decreased expression of the RNA-binding motif protein 28 ( RBM28). In this study, we attempted to delineate the role of RBM28 in hair biology. First, we sought to obtain evidence for the direct involvement of RBM28 in hair growth. When RBM28 was downregulated in human hair follicle ( HF) organ cultures, we observed catagen induction and HF growth arrest, indicating that RBM28 is necessary for normal hair growth. We also aimed at identifying molecular targets of RBM28. Given that an RBM28 homologue was recently found to regulate mi RNA biogenesis in C. elegans and given the known pivotal importance of mi RNAs for proper hair follicle development, we studied global mi RNA expression profile in cells knocked down for RBM28. This analysis revealed that RBM28 controls the expression of miR-203. miR-203 was found to regulate in turn TP63, encoding the transcription factor p63, which is critical for hair morphogenesis. In conclusion, RBM28 contributes to HF growth regulation through modulation of miR-203 and p63 activity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09066705
Volume :
24
Issue :
8
Database :
Complementary Index
Journal :
Experimental Dermatology
Publication Type :
Academic Journal
Accession number :
108593264
Full Text :
https://doi.org/10.1111/exd.12737