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Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth.

Authors :
Scott-Finley, M
Woo, J G
Habli, M
Ramos-Gonzales, O
Cnota, J F
Wang, Y
Kamath-Rayne, B D
Hinton, A C
Polzin, W J
Crombleholme, T M
Hinton, R B
Source :
Journal of Perinatology; Aug2015, Vol. 35 Issue 8, p547-552, 6p, 4 Charts, 1 Graph
Publication Year :
2015

Abstract

Objective:Leptin is an adipokine that regulates energy homeostasis. The objective of this study was to establish a gestational age-specific standard for amniotic fluid leptin (AFL) levels and examine the relationship between AFL, maternal overweight and fetal growth restriction.Study Design:Amniotic fluid was obtained at mid-gestation from singleton gravidas, and leptin was quantified using enzyme-linked immunosorbent assay. Amniotic fluid samples from 321 term pregnancies were analyzed. Clinical data, including fetal ultrasound measurements and maternal and infant characteristics, were available for a subset of patients (n=45).Results:The median interquartile range AFL level was significantly higher at 14 weeks' gestation (2133 pg ml<superscript>−1</superscript> (1703 to 4347)) than after 33 weeks' gestation (519 pg ml<superscript>−1</superscript> (380 to 761), P trend<0.0001), an average difference of 102 pg ml<superscript>−1</superscript> per week. AFL levels were positively correlated with maternal pre-pregnancy body mass index (BMI) (r=0.36, P=0.03) adjusting for gestational age at measurement, but were not associated with fetal growth.Conclusions:AFL levels are higher at mid-gestation than at late gestation, and are associated with maternal pre-pregnancy BMI. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07438346
Volume :
35
Issue :
8
Database :
Complementary Index
Journal :
Journal of Perinatology
Publication Type :
Academic Journal
Accession number :
108592464
Full Text :
https://doi.org/10.1038/jp.2015.39