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Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans.
- Source :
- Journal of Infectious Diseases; 9/1/2003, Vol. 188 Issue 5, p759-768, 10p
- Publication Year :
- 2003
-
Abstract
- In Escherichia coli infection, the implications of fluoroquinolone (FQ) and extended-spectrum cephalosporin plus cephamycin (AmpC) resistance for phylogenetic origin and virulence potential are undefined, as is the influence of ecological context on these associations. Accordingly, 106 E. coli isolates exhibiting FQ and/or AmpC resistance and 98 susceptible isolates were compared with regard to phylogenetic background and virulence profiles, stratified by host group (104 predominantly extraintestinal human isolates and 100 pre- dominantly intestinal cattle and swine isolates). Although resistant isolates exhibited significant shifts in phylogenetic distribution and virulence profiles, human and animal isolates exhibited different phylogenetic shifts, and only among human isolates did resistance predict reduced virulence. Evidence for similar strains being resistant versus susceptible was scant. The O15:K52:H1 clonal group and the closely related "clonal group A" featured prominently among resistant and susceptible human isolates, respectively. Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYLOGENY
MICROBIAL virulence
CEPHALOSPORINS
ESCHERICHIA coli
ANIMAL experimentation
ANTI-infective agents
BACTERIAL proteins
CATTLE
COMPARATIVE studies
DRUG resistance in microorganisms
ESCHERICHIA coli diseases
BIOLOGICAL evolution
HYDROLASES
RESEARCH methodology
MEDICAL cooperation
MICROBIAL sensitivity tests
QUINOLONE antibacterial agents
RESEARCH
SWINE
EVALUATION research
SEROTYPING
RAPD technique
GENOTYPES
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 188
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 10672599
- Full Text :
- https://doi.org/10.1086/377455